Complement System: An Immunotherapy Target in Colorectal Cancer

Iman M Talaat; Noha Mousaad Elemam; Maha Saber-Ayad

doi:10.3389/fimmu.2022.810993

Complement System: An Immunotherapy Target in Colorectal Cancer

Front Immunol. 2022 Jan 31:13:810993. doi: 10.3389/fimmu.2022.810993. eCollection 2022.

Authors

Iman M Talaat^{1

2

3}, Noha Mousaad Elemam^{1

2}, Maha Saber-Ayad^{1

2

4}

Affiliations

¹ College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
² Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
³ Faculty of Medicine, Alexandria University, Alexandria, Egypt.
⁴ Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract

Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system. The complement system is composed of several players, namely component molecules, regulators and receptors. In this review, we discuss the complement system activation in cancer specifically CRC and highlight the possible interactions between the complement system and the various TME components. Additionally, the role of the complement system in tumor immunity of CRC is reviewed. Hence, such work could provide a framework for researchers to further understand the role of the complement system in CRC and explore the potential therapies targeting complement activation in solid tumors such as CRC.

Keywords: colorectal cancer; complement system; immunotherapy; tumor immunity; tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Colorectal Neoplasms / immunology*
Colorectal Neoplasms / therapy
Complement Activation
Complement System Proteins / physiology*
Humans
Immunotherapy / methods*

Substances

Complement System Proteins