Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D Scott; Moriah R Arnold; Thomas G Beach; Christopher H Gibbons; Anumantha G Kanthasamy; Russell M Lebovitz; Afina W Lemstra; Leslie M Shaw; Charlotte E Teunissen; Henrik Zetterberg; Angela S Taylor; Todd C Graham; Bradley F Boeve; Stephen N Gomperts; Neill R Graff-Radford; Charbel Moussa; Kathleen L Poston; Liana S Rosenthal; Marwan N Sabbagh; Ryan R Walsh; Miriam T Weber; Melissa J Armstrong; Jee A Bang; Andrea C Bozoki; Kimiko Domoto-Reilly; John E Duda; Jori E Fleisher; Douglas R Galasko; James E Galvin; Jennifer G Goldman; Samantha K Holden; Lawrence S Honig; Daniel E Huddleston; James B Leverenz; Irene Litvan; Carol A Manning; Karen S Marder; Alexander Y Pantelyat; Victoria S Pelak; Douglas W Scharre; Sharon J Sha; Holly A Shill; Zoltan Mari; Joseph F Quinn; David J Irwin

doi:10.3389/fneur.2021.805135

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Front Neurol. 2022 Jan 31:12:805135. doi: 10.3389/fneur.2021.805135. eCollection 2021.

Authors

Gregory D Scott^{1

2}, Moriah R Arnold³, Thomas G Beach⁴, Christopher H Gibbons⁵, Anumantha G Kanthasamy⁶, Russell M Lebovitz⁷, Afina W Lemstra⁸, Leslie M Shaw⁹, Charlotte E Teunissen¹⁰, Henrik Zetterberg^{11

12

13

14

15}, Angela S Taylor¹⁶, Todd C Graham¹⁶, Bradley F Boeve¹⁷, Stephen N Gomperts¹⁸, Neill R Graff-Radford¹⁹, Charbel Moussa²⁰, Kathleen L Poston²¹, Liana S Rosenthal²², Marwan N Sabbagh²³, Ryan R Walsh²⁴, Miriam T Weber²⁵, Melissa J Armstrong²⁶, Jee A Bang²⁷, Andrea C Bozoki²⁸, Kimiko Domoto-Reilly²⁹, John E Duda^{30

31}, Jori E Fleisher³², Douglas R Galasko³³, James E Galvin³⁴, Jennifer G Goldman³⁵, Samantha K Holden³⁶, Lawrence S Honig³⁷, Daniel E Huddleston³⁸, James B Leverenz³⁹, Irene Litvan³³, Carol A Manning⁴⁰, Karen S Marder³⁷, Alexander Y Pantelyat²⁷, Victoria S Pelak⁴¹, Douglas W Scharre⁴², Sharon J Sha²¹, Holly A Shill²³, Zoltan Mari⁴³, Joseph F Quinn^{44

45}, David J Irwin^{46

47

48

49}

Affiliations

¹ Department of Pathology, Oregon Health and Science University, Portland, OR, United States.
² Department of Pathology and Laboratory Services, VA Portland Medical Center, Portland, OR, United States.
³ Graduate Program in Biomedical Sciences, School of Medicine M.D./Ph.D. Program, Oregon Health and Science University, Portland, OR, United States.
⁴ Civin Laboratory for Neuropathology and Brain and Body Donation Program, Banner Sun Health Research Institute, Sun City, AZ, United States.
⁵ Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
⁶ Department of Physiology and Pharmacology, Center for Brain Sciences and Neurodegenerative Diseases, University of Georgia, Athens, GA, United States.
⁷ Amprion Inc., San Francisco, CA, United States.
⁸ Department of Neurology, Amsterdam University Medical Center (UMC), Alzheimer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
⁹ Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
¹⁰ Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
¹¹ Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
¹² Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
¹³ Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London, United Kingdom.
¹⁴ UK Dementia Research Institute at University College London, London, United Kingdom.
¹⁵ Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
¹⁶ Lewy Body Dementia Association, Lilburn, GA, United States.
¹⁷ Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United States.
¹⁸ Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.
¹⁹ Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.
²⁰ Department of Neurology, Georgetown University Medical Center, Washington DC, CA, United States.
²¹ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States.
²² Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States.
²³ Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States.
²⁴ Barrow Neurological Institute and Muhammed Ali Parkinson Center, Phoenix, AZ, United States.
²⁵ Department of Neurology, University of Rochester, Rochester, NY, United States.
²⁶ Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States.
²⁷ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
²⁸ Department of Neurology, University of North Carolina, Chapel Hill, NC, United States.
²⁹ Department of Neurology, University of Washington, Seattle, WA, United States.
³⁰ Parkinson's Disease Research, Education and Clinical Center, Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States.
³¹ Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
³² Department of Neurological Sciences, Rush Medical College, Chicago, IL, United States.
³³ Department of Neurosciences, University of California, San Diego, San Diego, CA, United States.
³⁴ Department of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Miami, FL, United States.
³⁵ Shirley Ryan Abilitylab and Department of Physical Medicine and Rehabilitation and Neurology, Parkinson's Disease and Movement Disorders, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
³⁶ Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States.
³⁷ Columbia University Irving Medical Center, New York, NY, United States.
³⁸ Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
³⁹ Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, United States.
⁴⁰ Department of Neurology, University of Virginia, Charlottesville, VA, United States.
⁴¹ Departments of Neurology and Ophthalmology, University of Colorado School of Medicine, Aurora, CO, United States.
⁴² Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, United States.
⁴³ Lou Ruvo Center for Brain Health, Cleveland Clinic Lerner College of Medicine, Las Vegas, NV, United States.
⁴⁴ Department of Neurology, Oregon Health and Science University, Portland, OR, United States.
⁴⁵ Department of Neurology, VA Portland Medical Center, Portland, OR, United States.
⁴⁶ Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA, United States.
⁴⁷ Digital Neuropathology Laboratory, Philadelphia, PA, United States.
⁴⁸ Lewy Body Disease Research Center of Excellence, Philadelphia, PA, United States.
⁴⁹ Frontotemporal Degeneration Center, Philadelphia, PA, United States.

Abstract

The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and Parkinson's disease dementia (PDD). The meeting featured eight internationally known scientists from Europe and the United States and attracted over 200 scientists and physicians from academic centers, the National Institutes of Health, and the pharmaceutical industry. Methods for confirming and quantifying the presence of Lewy body and Alzheimer's pathology and novel biomarkers were discussed.

Keywords: LBDA biomarker symposium; Lewy body dementia; alpha-synuclein; amyloid; cerebrospinal fluid; seeded aggregation assays; skin biopsy; tau.

Copyright © 2022 Scott, Arnold, Beach, Gibbons, Kanthasamy, Lebovitz, Lemstra, Shaw, Teunissen, Zetterberg, Taylor, Graham, Boeve, Gomperts, Graff-Radford, Moussa, Poston, Rosenthal, Sabbagh, Walsh, Weber, Armstrong, Bang, Bozoki, Domoto-Reilly, Duda, Fleisher, Galasko, Galvin, Goldman, Holden, Honig, Huddleston, Leverenz, Litvan, Manning, Marder, Pantelyat, Pelak, Scharre, Sha, Shill, Mari, Quinn and Irwin.

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Review

Abstract

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