Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo-controlled, double-blind clinical trial

PLoS One. 2022 Feb 16;17(2):e0263971. doi: 10.1371/journal.pone.0263971. eCollection 2022.

Abstract

This study is a randomized, placebo-controlled, double-blinded trial performed to investigate the effects of a dietary supplement containing a mixture of Boswellia serrata Roxb., chlorophyll, green tea extract, glucosamine, chondroitin sulfate, hyaluronic acid, and further in the manuscript: non-hydrolised type II collagen in dogs with osteoarthritis (OA). A total of 40 dogs were enrolled in the study, they were randomly divided in control (CTR) and treatment (TRT) groups. The TRT group received the dietary supplement for 60 days. The CTR group received a placebo for the same number of days. All the subjects had veterinary evaluations during the trial and owners were requested to fill in questionnaires on chronic pain using the Helsinki Chronic Pain Index. The product was easy to administer and no side effects were reported. Combining results from veterinarian and owner evaluations, the tested product proved to be significantly beneficial in alleviating pain and in reducing the clinical signs in dogs with OA.

Publication types

  • Randomized Controlled Trial, Veterinary
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chondroitin Sulfates / administration & dosage*
  • Dietary Supplements*
  • Dogs
  • Double-Blind Method
  • Glucosamine / administration & dosage*
  • Hyaluronic Acid / administration & dosage*
  • Male
  • Osteoarthritis, Knee / diet therapy*
  • Treatment Outcome
  • Viscosupplements / administration & dosage

Substances

  • Viscosupplements
  • Hyaluronic Acid
  • Chondroitin Sulfates
  • Glucosamine

Grants and funding

Candioli Pharma Srl supported the study by providing the supplement to the owners, paying the publication charges, and supervising the study to be sure that it was adhering to the planned scientific protocol. The funders had no role in decision to publish or preparation of the manuscript.