Tuberculosis in Children

Devan Jaganath; Jeanette Beaudry; Nicole Salazar-Austin

doi:10.1016/j.idc.2021.11.008

Tuberculosis in Children

Infect Dis Clin North Am. 2022 Mar;36(1):49-71. doi: 10.1016/j.idc.2021.11.008.

Authors

Devan Jaganath¹, Jeanette Beaudry², Nicole Salazar-Austin³

Affiliations

¹ Division of Pediatric Infectious Diseases, University of California, San Francisco, 1001 Potrero Avenue, Building 3, Room 635A, Box 1234, San Francisco, CA 94110, USA.
² Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 200 N. Wolfe Street, Room 3150, Baltimore, MD 21287, USA.
³ Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 200 N Wolfe Street, Room 3147, Baltimore, MD 21287, USA. Electronic address: nsalaza1@jhmi.edu.

Abstract

Tuberculosis (TB) is one of the leading causes of mortality in children worldwide, but there remain significant challenges in diagnosing and treating TB infection and disease. Treatment of TB infection in children and adolescents is critical to prevent progression to TB disease and to prevent them from becoming the future reservoir for TB transmission. This article reviews the clinical approach to diagnosing and treating latent TB infection and pulmonary and extrapulmonary TB disease in children. Also discussed are emerging diagnostics and therapeutic regimens that aim to improve pediatric TB detection and outcomes.

Keywords: Child; Diagnosis; Prevention; TB; Treatment; Tuberculosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Child
Humans
Tuberculosis* / diagnosis
Tuberculosis* / drug therapy
Tuberculosis* / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding