Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

Henrik Christian Bidstrup Leffers; David Westergaard; Saedis Saevarsdottir; Ingileif Jonsdottir; Ole Birger Pedersen; DBDS genomic consortium; Anne Troldborg; Anne Voss; Salome Kristensen; Jesper Lindhardsen; Prabhat Kumar; Asta Linauskas; Lars Juul; Niels Steen Krogh; Bent Deleuran; Lene Dreyer; Michael Schwinn; Lise Wegner Thørner; Lotte Hindhede; Christian Erikstrup; Henrik Ullum; Søren Brunak; Kari Stefansson; Karina Banasik; Søren Jacobsen

doi:10.1016/j.jbspin.2022.105357

Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study

Joint Bone Spine. 2022 Jul;89(4):105357. doi: 10.1016/j.jbspin.2022.105357. Epub 2022 Feb 12.

Authors

Henrik Christian Bidstrup Leffers¹, David Westergaard², Saedis Saevarsdottir³, Ingileif Jonsdottir³, Ole Birger Pedersen⁴; DBDS genomic consortium⁵; Anne Troldborg⁶, Anne Voss⁷, Salome Kristensen⁸, Jesper Lindhardsen⁹, Prabhat Kumar¹⁰, Asta Linauskas¹¹, Lars Juul¹¹, Niels Steen Krogh¹², Bent Deleuran⁶, Lene Dreyer¹³, Michael Schwinn², Lise Wegner Thørner¹⁴, Lotte Hindhede¹⁵, Christian Erikstrup¹⁵, Henrik Ullum¹⁴, Søren Brunak², Kari Stefansson³, Karina Banasik², Søren Jacobsen¹⁶

Affiliations

¹ Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; The DANBIO Registry, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark. Electronic address: hcl@dadlnet.dk.
² The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and medical Sciences, University of Copenhagen, Copenhagen, Denmark.
³ deCODE genetics/Amgen, Inc, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
⁴ Department of Clinical Immunology, Zealand University Hospital, Næstved, Denmark.
⁵ Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
⁶ Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital, Aarhus N, Denmark.
⁷ Department of Rheumatology, Odense University Hospital, Odense, Denmark.
⁸ The DANBIO Registry, Copenhagen, Denmark; Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.
⁹ Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
¹⁰ Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark.
¹¹ Department of Rheumatology, Centre for Rheumatology and Spine Diseases, Gentofte Hospital, Copenhagen, Denmark.
¹² The DANBIO Registry, Copenhagen, Denmark; Zitelab ApS, Copenhagen, Denmark.
¹³ The DANBIO Registry, Copenhagen, Denmark; Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark; Clinical Institute Aalborg University, Aalborg, Denmark.
¹⁴ Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁵ Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
¹⁶ Copenhagen Lupus and Vasculitis Clinic, Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.

PMID: 35167971
DOI: 10.1016/j.jbspin.2022.105357

No abstract available

Keywords: Clinical phenotype; Disease manifestations; GWAS; Genome wide association study; Lupus Nephritis; SLE; Systemic Lupus Erythematosus.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CD11b Antigen / genetics
Case-Control Studies
Denmark / epidemiology
Genetic Predisposition to Disease
Genome-Wide Association Study*
Humans
Interferon Regulatory Factors / genetics
Lupus Erythematosus, Systemic* / genetics
NADPH Oxidases
Polymorphism, Single Nucleotide
STAT4 Transcription Factor
beta Karyopherins

Substances

CD11b Antigen
IRF5 protein, human
ITGAM protein, human
Interferon Regulatory Factors
STAT4 Transcription Factor
STAT4 protein, human
TNPO3 protein, human
beta Karyopherins
NADPH Oxidases
NCF2 protein, human