Antibiofilm Effect of Curcumin Against Staphylococcus aureus Surface Wound Biofilm-Associated Infection: In Vitro and In Silico

Abstract

Biofilm is the consortia of the sessile group of microbial species that are adhered to the biotic and abiotic surfaces with the help of extracellular polymeric substances (EPS) and glycocalyx. A wound is a lesion on the epidermal surface that exposes the underlying tissues to the external environment and thus forms a region of proliferation for several species of Staphylococcus aureus. S. aureus is the most commonly observed nosocomial biofilm-forming organism that is responsible for the development of wound-associated infections. The biofilm prevents the penetration of the drug molecules thereby resulting in the development of antibiotic and multi-drug resistance among the organism. Thus, the use of alternative therapeutics has paved the path in the treatment of biofilm-associated infections. Curcumin has been used for the purpose of treating various illnesses from time immemorial. In this study, we observed that curcumin was able to bring about a reduction in the biofilm formed by S. aureus in the wound infection among the patients. The in silico studies revealed that curcumin possessed the ability to bring about interaction with the biofilm-forming proteins of S. aureus effectively.

Keywords: Antibiofilm; Bioactive compound; Molecular docking; Surface wound biofilm.