Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

Int J Mol Sci. 2022 Jan 27;23(3):1445. doi: 10.3390/ijms23031445.

Abstract

Bioactive peptides are a group of biological molecules that are normally buried in the structure of parent proteins and become active after the cleavage of the proteins. Another group of peptides is actively produced and found in many microorganisms and the body of organisms. Today, many groups of bioactive peptides have been marketed chemically or recombinantly. This article reviews the various production methods and sources of these important/ubiquitous and useful biomolecules. Their applications, such as antimicrobial, antihypertensive, antioxidant activities, blood-lipid-lowering effect, opioid role, antiobesity, ability to bind minerals, antidiabetic, and antiaging effects, will be explored. The types of pathways proposed for bioactive applications will be in the next part of the article, and at the end, the future perspectives of bioactive peptides will be reviewed. Reading this article is recommended for researchers interested in various fields of physiology, microbiology, biochemistry, and nanotechnology and food industry professionals.

Keywords: application of peptides; bioactive peptides; mechanism of application; production of peptides.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Factors / chemistry
  • Biological Factors / isolation & purification
  • Biological Factors / pharmacology*
  • Drug Industry
  • Food Industry
  • Humans
  • Peptides / chemistry
  • Peptides / isolation & purification
  • Peptides / pharmacology*

Substances

  • Biological Factors
  • Peptides