The Versatility in the Applications of Dithiocarbamates

Int J Mol Sci. 2022 Jan 24;23(3):1317. doi: 10.3390/ijms23031317.

Abstract

Dithiocarbamate ligands have the ability to form stable complexes with transition metals, and this chelating ability has been utilized in numerous applications. The complexes have also been used to synthesize other useful compounds. Here, the up-to-date applications of dithiocarbamate ligands and complexes are extensively discussed. Some of these are their use as enzyme inhibitor and treatment of HIV and other diseases. The application as anticancer, antimicrobial, medical imaging and anti-inflammatory agents is examined. Moreover, the application in the industry as vulcanization accelerator, froth flotation collector, antifouling, coatings, lubricant additives and sensors is discussed. The various ways in which they have been employed in synthesis of other compounds are highlighted. Finally, the agricultural uses and remediation of heavy metals via dithiocarbamate compounds are comprehensively discussed.

Keywords: agricultural applications; dithiocarbamate; industrial applications; medical use; metal complexes.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Enzyme Inhibitors
  • Humans
  • Ligands
  • Metals, Heavy
  • Thiocarbamates / chemical synthesis*
  • Thiocarbamates / chemistry*
  • Thiocarbamates / pharmacology
  • Transition Elements / chemistry*

Substances

  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Ligands
  • Metals, Heavy
  • Thiocarbamates
  • Transition Elements