Emerging resistance to beta-lactams in Pantoea ananatis isolated from an immunocompetent patient with bacteremia

Michinobu Yoshimura; Chiemi Tokushige; Jun-Ichi Maruyama; Yasumasa Kawano; Hiroyasu Ishikura; Akira Matsunaga; Tohru Takata; Kenji Hiromatsu; Itaru Yanagihara; Atsushi Togawa; Yasushi Takamatsu

doi:10.1016/j.diagmicrobio.2022.115633

Emerging resistance to beta-lactams in Pantoea ananatis isolated from an immunocompetent patient with bacteremia

Diagn Microbiol Infect Dis. 2022 Apr;102(4):115633. doi: 10.1016/j.diagmicrobio.2022.115633. Epub 2022 Jan 15.

Affiliations

¹ Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Osaka, Japan; Department of Microbiology and Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. Electronic address: myoshimura@fukuoka-u.ac.jp.
² Department of Clinical Laboratory, Fukuoka University Hospital, Fukuoka, Japan.
³ Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka, Japan.
⁴ Department of Infection Control and Prevention, Fukuoka University Hospital, Fukuoka, Japan; Department of Medical Oncology, Hematology, and Infectious Diseases, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
⁵ Department of Microbiology and Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
⁶ Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Osaka, Japan.
⁷ Department of Infection Control and Prevention, Fukuoka University Hospital, Fukuoka, Japan; Department of Medical Oncology, Hematology, and Infectious Diseases, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. Electronic address: atogawa@fukuoka-u.ac.jp.
⁸ Department of Medical Oncology, Hematology, and Infectious Diseases, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

PMID: 35158291
DOI: 10.1016/j.diagmicrobio.2022.115633

Abstract

We observed an emerging resistance to β-lactams in a P. ananatis bacteremia case. Whole genome sequence analysis detected two β-lactamase genes as well as related genes that regulate the β-lactamase genes in the chromosome. The induction experiment resulted in the expression of the class A β-lactamase gene in the isolate.

Keywords: Antibiotic resistance; Class A β-lactamase; Pantoea ananatis; Whole genome sequencing.

MeSH terms

Bacteremia* / diagnosis
Bacteremia* / drug therapy
Humans
Pantoea* / genetics
beta-Lactams / pharmacology

Substances

beta-Lactams

Supplementary concepts

Pantoea ananatis