Management of the parotid for high-risk cutaneous squamous cell carcinoma: A review from the salivary section of the American Head and Neck Society

Alexandra E Kejner; Brianna N Harris; Rusha Patel; Caitlin McMullen; Joshua Weir; Basem A Dahshan; William R Carroll; M Boyd Gillespie

doi:10.1016/j.amjoto.2022.103374

Management of the parotid for high-risk cutaneous squamous cell carcinoma: A review from the salivary section of the American Head and Neck Society

Am J Otolaryngol. 2022 Mar-Apr;43(2):103374. doi: 10.1016/j.amjoto.2022.103374. Epub 2022 Feb 2.

Authors

Alexandra E Kejner¹, Brianna N Harris², Rusha Patel³, Caitlin McMullen⁴, Joshua Weir⁵, Basem A Dahshan⁵, William R Carroll⁶, M Boyd Gillespie⁷

Affiliations

¹ Department of Otolaryngology - Head and Neck Surgery, University of Kentucky Markey Cancer Center, Lexington, KY, USA. Electronic address: Alexandra.kejner@uky.edu.
² Sharp Memorial - Department of Otolaryngology, San Diego, CA, USA.
³ Department of Otolaryngology, University of Oklahoma, Oklahoma City, OK, USA.
⁴ Department of Head and Neck - Endocrine Oncology, Moffitt Cancer Center, Tampa, FL, USA.
⁵ Department of Radiation Oncology, West Virginia University, Morgantown, WV, USA.
⁶ Department of Otolaryngology - Head and Neck Surgery, University of Alabama - Birmingham, Birmingham, AL, USA.
⁷ Department of Otolaryngology - Head and Neck Surgery, University of Tennessee - Memphis, Memphis, TN, USA.

PMID: 35158264
DOI: 10.1016/j.amjoto.2022.103374

Abstract

Background: Metastases to the parotid nodal basin in patients with high-risk cutaneous squamous cell carcinoma (HRcSCC) impact disease specific survival (DSS) and overall survival (OS).

Methods: A writing group convened by the Salivary Section of the American Head and Neck Society (AHNS) developed contemporary, evidence-based recommendations regarding management of the parotid nodal basin in HRcSCC based on available literature, expert consultation, and collective experience. The statements and recommendations were then submitted and approved by the AHNS Salivary Committee.

Results: These recommendations were developed given the wide variation of practitioners who treat HRcSCC in order to streamline management of the parotid nodal basin including indications for imaging, surgery, radiation, and systemic treatment options as well.

Conclusions: This clinical update represents contemporary optimal management of the parotid nodal basin in HRcSCC and is endorsed by the Salivary Section of the AHNS.

Keywords: Cutaneous squamous cell carcinoma; Elective parotidectomy; High risk cutaneous squamous cell carcinoma; Parotid metastases; Parotid nodal basin.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell* / pathology
Head and Neck Neoplasms* / pathology
Head and Neck Neoplasms* / therapy
Humans
Lymph Nodes / pathology
Neoplasm Staging
Parotid Gland / surgery
Parotid Neoplasms* / pathology
Parotid Neoplasms* / therapy
Retrospective Studies
Skin Neoplasms* / pathology
United States