T cell responses to SARS-CoV-2 in humans and animals

Sameer-Ul-Salam Mattoo; Jinjong Myoung

doi:10.1007/s12275-022-1624-z

T cell responses to SARS-CoV-2 in humans and animals

J Microbiol. 2022 Mar;60(3):276-289. doi: 10.1007/s12275-022-1624-z. Epub 2022 Feb 14.

Authors

Sameer-Ul-Salam Mattoo¹, Jinjong Myoung²

Affiliations

¹ Korea Zoonosis Research Institute, Department of Bioactive Material Science and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju, 54531, Republic of Korea.
² Korea Zoonosis Research Institute, Department of Bioactive Material Science and Genetic Engineering Research Institute, Jeonbuk National University, Jeonju, 54531, Republic of Korea. jinjong.myoung@jbnu.ac.kr.

Abstract

SARS-CoV-2, the causative agent of COVID-19, first emerged in 2019. Antibody responses against SARS-CoV-2 have been given a lot of attention. However, the armamentarium of humoral and T cells may have differing roles in different viral infections. Though the exact role of T cells in COVID-19 remains to be elucidated, prior experience with human coronavirus has revealed an essential role of T cells in the outcomes of viral infections. Moreover, an increasing body of evidence suggests that T cells might be effective against SARS-CoV-2. This review summarizes the role of T cells in mouse CoV, human pathogenic respiratory CoV in general and SARS-CoV-2 in specific.

Keywords: SARS-CoV-2; T cell; coronavirus; immune response.

Publication types

Review

MeSH terms

Animals
Antibodies, Viral
COVID-19*
Humans
Mice
SARS-CoV-2*
T-Lymphocytes

Substances

Antibodies, Viral