Automatic retinal nerve fiber bundle tracing based on large field of view polarization sensitive OCT data

Florian Schwarzhans; Sylvia Desissaire; Stefan Steiner; Michael Pircher; Christoph K Hitzenberger; Hemma Resch; Clemens Vass; Georg Fischer

doi:10.1364/BOE.443958

Automatic retinal nerve fiber bundle tracing based on large field of view polarization sensitive OCT data

Biomed Opt Express. 2021 Dec 3;13(1):65-81. doi: 10.1364/BOE.443958. eCollection 2022 Jan 1.

Authors

Florian Schwarzhans^{1

2}, Sylvia Desissaire³, Stefan Steiner⁴, Michael Pircher³, Christoph K Hitzenberger³, Hemma Resch⁴, Clemens Vass⁴, Georg Fischer²

Affiliations

¹ Department of Clinical Pharmacology, Medical University Vienna, Vienna, 1090, Austria.
² Center for Medical Statistics, Informatics and Intelligent Systems, Medical University Vienna, Vienna, 1090, Austria.
³ Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, 1090, Austria.
⁴ Department of Ophthalmology and Optometry, Medical University Vienna, Vienna, 1090, Austria.

Abstract

A technique to accurately estimate trajectories of retinal nerve fiber bundles (RNFB) in a large field of view (FOV) image covering 45° is described. The method utilizes stitched projections of polarization-sensitive optical coherence tomography (PS-OCT) data, as well as a mathematical model of average RNFB trajectories as prior. The fully automatic process was applied to data recorded in healthy subjects and glaucoma patients and automatically detected individual RNFB trajectories are compared to manual traces.

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