Distinguishing Cardiac Amyloidosis and Hypertrophic Cardiomyopathy by Thickness and Myocardial Deformation of the Right Ventricle

Hui Liu; Peng Bai; Hua-Yan Xu; Zhen-Lin Li; Chun-Chao Xia; Xiao-Yue Zhou; Liang-Geng Gong; Ying-Kun Guo

doi:10.1155/2022/4364279

Distinguishing Cardiac Amyloidosis and Hypertrophic Cardiomyopathy by Thickness and Myocardial Deformation of the Right Ventricle

Cardiol Res Pract. 2022 Feb 1:2022:4364279. doi: 10.1155/2022/4364279. eCollection 2022.

Authors

Hui Liu¹, Peng Bai², Hua-Yan Xu³, Zhen-Lin Li⁴, Chun-Chao Xia⁴, Xiao-Yue Zhou⁵, Liang-Geng Gong¹, Ying-Kun Guo³

Affiliations

¹ Department of Radiology, Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.
² Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
³ Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education; West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
⁴ Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
⁵ MR Collaboration, Siemens Healthcare Ltd., Shanghai, China.

Abstract

Objectives: To compare right ventricular thickness (RVT) and deformation of cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) patients.

Methods: Sixty CA (mean age 58 ± 10 years; 33 males (55%)) and sixty HCM patients (mean age 55 ± 14 years; 27 males (45%)) were retrospectively enrolled. RVT, global radical peak strain (GRPS), global longitudinal peak strain (GLPS), and global circumferential peak stain (GCPS) were analyzed. To determine the cutoff values of the RVT and RV strain parameters for distinguishing CA from HCM, the areas under the receiver operating characteristic curve (AUCs) were analyzed.

Results: RVT of CA patients was significantly thicker than that of HCM patients (7.8 ± 2.1 vs 5.9 ± 1.3, p < 0.001). Moreover, significantly decreased RV-GRPS (12.1 ± 6.9 vs 23.5 ± 12.1, p < 0.001), RV-GCPS (-3.4 ± 2.2 vs -5.6 ± 3.5, p < 0.001), and RV-GLPS (-4.6 ± 2.3 vs -11.1 ± 4.9, p < 0.001) were observed in CA patients compared with HCM patients. RVT and RV strain demonstrate comparable diagnostic accuracy in differentiating CA from HCM. In particular, RV-GLPS combined with RVT showed the best performance for discriminating CA from HCM (AUC = 0.92, 95% CI: 0.85 to 0.96, p = 0.0001).

Conclusions: Right ventricular myocardial thickness and deformation of CA patients was more severe than HCM patients. RV-GLPS combined with RVT presents an excellent diagnostic performance in distinguishing CA and HCM.