Endothelial cells: major players in acute myeloid leukaemia

Sofiane Fodil; Marine Arnaud; Camille Vaganay; Alexandre Puissant; Etienne Lengline; Nuala Mooney; Raphael Itzykson; Lara Zafrani

doi:10.1016/j.blre.2022.100932

Endothelial cells: major players in acute myeloid leukaemia

Blood Rev. 2022 Jul:54:100932. doi: 10.1016/j.blre.2022.100932. Epub 2022 Feb 2.

Authors

Sofiane Fodil¹, Marine Arnaud², Camille Vaganay³, Alexandre Puissant⁴, Etienne Lengline⁵, Nuala Mooney⁶, Raphael Itzykson⁷, Lara Zafrani⁸

Affiliations

¹ Medical Intensive Care Unit, Saint Louis Hospital, Assistance Publique des Hôpitaux de Paris, University of Paris, Paris, France; University of Paris, Immunologie Humaine, Pathophysiologie, Immunothérapie UMR 976, INSERM, Paris, France. Electronic address: sofiane.fodil@aphp.fr.
² University of Paris, Immunologie Humaine, Pathophysiologie, Immunothérapie UMR 976, INSERM, Paris, France. Electronic address: marine.arnaud@inserm.fr.
³ University of Paris, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010 Paris, France. Electronic address: camille.vaganay@inserm.fr.
⁴ University of Paris, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010 Paris, France. Electronic address: alexandre.puissant@inserm.fr.
⁵ Adult Hematology Unit, Assistance Publique des Hôpitaux de Paris, University of Paris, Paris, France. Electronic address: etienne.lengline@aphp.fr.
⁶ University of Paris, Immunologie Humaine, Pathophysiologie, Immunothérapie UMR 976, INSERM, Paris, France. Electronic address: nuala.mooney@paris7.jussieu.fr.
⁷ University of Paris, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010 Paris, France; Adult Hematology Unit, Assistance Publique des Hôpitaux de Paris, University of Paris, Paris, France. Electronic address: raphael.itzykson@aphp.fr.
⁸ Medical Intensive Care Unit, Saint Louis Hospital, Assistance Publique des Hôpitaux de Paris, University of Paris, Paris, France; University of Paris, Immunologie Humaine, Pathophysiologie, Immunothérapie UMR 976, INSERM, Paris, France. Electronic address: lara.zafrani@aphp.fr.

PMID: 35148910
DOI: 10.1016/j.blre.2022.100932

Abstract

The role of the vascular microenvironment is increasingly studied in acute myeloid leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic cells may contribute to the clonal evolution of pre-leukaemic stem cells in the bone marrow niche and to the proliferation, survival and chemoresistance of leukaemic cells. Through the expression of different adhesion molecules, ECs play a key role in the development of specific acute complications of AML, including leukostasis, acute respiratory failure, acute kidney injury or neurological complications. Moreover, in newly diagnosed patients, leukaemic cells promote endothelial activation and subsequent disseminated intravascular coagulation. Mechanisms of this bi-directional dialogue between leukaemic cells and ECs will reveal possible therapeutic targets to be explored to improve the survival of AML patients.

Keywords: Acute myeloid leukaemia; Endothelial cell; Hematopoietic stem cell.

Publication types

Review

MeSH terms

Bone Marrow / metabolism
Bone Marrow Cells / metabolism
Clonal Evolution
Endothelial Cells* / metabolism
Humans
Leukemia, Myeloid, Acute* / metabolism
Tumor Microenvironment / physiology