Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

Latifah A Alshabanah; Laila A Al-Mutabagani; Sobhi M Gomha; Hoda A Ahmed

doi:10.3389/fchem.2021.762248

Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

Front Chem. 2022 Jan 25:9:762248. doi: 10.3389/fchem.2021.762248. eCollection 2021.

Authors

Latifah A Alshabanah¹, Laila A Al-Mutabagani¹, Sobhi M Gomha^{2

3}, Hoda A Ahmed^{2

4}

Affiliations

¹ Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
² Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.
³ Chemistry Department, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.
⁴ Chemistry Department, College of Sciences, Taibah University, Yanbu, Saudi Arabia.

Abstract

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.

Keywords: acetylcoumarin; anticancer; hydrazonoyl halides; multicomponent synthesis; ultrasonic radiation.