Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Yafang Lu; Yaqiong Lu; Jun Meng; Zuo Wang

doi:10.3389/fphys.2021.791848

Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Front Physiol. 2022 Jan 25:12:791848. doi: 10.3389/fphys.2021.791848. eCollection 2021.

Authors

Yafang Lu¹, Yaqiong Lu¹, Jun Meng², Zuo Wang¹

Affiliations

¹ Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, China.
² Functional Department, The First Affiliated Hospital, University of South China, Hengyang, China.

Abstract

Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.

Keywords: NLRP3 inflammasome; caspase-1; diabetic cardiomyopathy; pyroptosis; regulation.

Publication types

Review