The role of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type receptor modulators in object recognition memory reconsolidation

Neuroreport. 2022 Mar 2;33(4):199-203. doi: 10.1097/WNR.0000000000001769.

Abstract

Objective: Numerous studies suggest that the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type (AMPA) receptor appears to play a central role in mediating brain functions, such as learning and memory. Trafficking of this receptor is related to different long-term memory processes. This study explores the role of two AMPA receptor (AMPAR) modulators in object recognition memory (ORM) reconsolidation.

Methods: First, the effects of immediate administration of each drug after memory reactivation were investigated and compared. Then, this drug's efficient time window and its effects without memory reactivation were investigated.

Results: Immediate CX546 administration after reactivation did not affect ORM reconsolidation. In contrast, administration of 10-mg/kg NBQX significantly impaired ORM reconsolidation within a 6-h time window. Importantly, the observed effects were not attributed to the exploratory behavior or locomotor activity of mice.

Conclusion: These findings provide new evidence that the AMPA receptor plays an important role in the reconsolidation phase of ORM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dioxoles / pharmacology
  • Learning
  • Memory Consolidation*
  • Memory, Long-Term*
  • Mice
  • Piperidines / pharmacology
  • Quinoxalines / pharmacology
  • Receptors, AMPA* / physiology
  • Recognition, Psychology*

Substances

  • 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine
  • Dioxoles
  • Piperidines
  • Quinoxalines
  • Receptors, AMPA
  • 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline