Deep eutectic solvents comprising creatine and citric acid and their hydrated mixtures

Chem Commun (Camb). 2022 Feb 24;58(17):2838-2841. doi: 10.1039/d1cc06088k.

Abstract

We report the phase diagram for the binary creatine-citric acid mixture which features a stable and broad eutectic region. Combinations containing 10-60 mol% creatine yield a deep eutectic solvent with a glass transition temperature at 270 K. Addition of up to 70 mol% water to the binary mixture affords retention of the eutectic nature and a handle to vary solvent viscosity and polarity.