Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Ruinan Hao; Zhuoyi Cui; Xindan Zhang; Ming Tian; Liqun Zhang; Feng Rao; Jiajia Xue

doi:10.3389/fchem.2021.839055

Rational Design and Preparation of Functional Hydrogels for Skin Wound Healing

Front Chem. 2022 Jan 24:9:839055. doi: 10.3389/fchem.2021.839055. eCollection 2021.

Authors

Ruinan Hao¹, Zhuoyi Cui¹, Xindan Zhang¹, Ming Tian², Liqun Zhang^{1

2}, Feng Rao^{3

4}, Jiajia Xue^{1

2}

Affiliations

¹ Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, China.
² State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China.
³ Trauma Center, Peking University People's Hospital, Beijing, China.
⁴ Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, National Trauma Medical Center, Peking University, Beijing, China.

Abstract

Skin wound healing often contains a series of dynamic and complex physiological healing processes. It is a great clinical challenge to effectively treat the cutaneous wound and regenerate the damaged skin. Hydrogels have shown great promise for skin wound healing through the rational design and preparation to endow with specific functionalities. In the mini review, we firstly introduce the design and construction of various types of hydrogels based on their bonding chemistry during cross-linking. Then, we summarize the recent research progress on the functionalization of bioactive hydrogel dressings for skin wound healing, including anti-bacteria, anti-inflammatory, tissue proliferation and remodeling. In addition, we highlight the design strategies of responsive hydrogels to external physical stimuli. Ultimately, we provide perspectives on future directions and challenges of functional hydrogels for skin wound healing.

Keywords: bioactive materials; hydrogel; skin wound healing; tissue regeneration; wound dressing.

Publication types

Review