IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

Biying Huang; Long Wang; Kui Tang; Sijie Chen; Yan Xu; Haiqin Liao; Chengcheng Niu

doi:10.3389/fchem.2022.840598

IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

Front Chem. 2022 Jan 24:10:840598. doi: 10.3389/fchem.2022.840598. eCollection 2022.

Authors

Biying Huang^{1

2}, Long Wang^{3

4

5

6}, Kui Tang^{1

2}, Sijie Chen^{1

2}, Yan Xu^{1

2}, Haiqin Liao^{1

2}, Chengcheng Niu^{1

2}

Affiliations

¹ Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
² Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China.
³ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
⁴ Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
⁶ Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Multidrug-resistant (MDR) bacterial strains have emerged and weakened the therapeutic effects of antibacterial drugs. Sonodynamic therapy (SDT) takes advantage of noninvasiveness and deep tissue-penetrating features and has been rejuvenated to combat MDR bacteria and their biofilm-associated infections. To improve the efficacy of antibacterial SDT, we first developed IR780-based PLGA nanoparticles as sonosensitizers for high-frequency ultrasound (US)-monitored antibacterial SDT of MRSA myositis by therapeutic low-frequency US. In this study, the developed shell-core-structured IR780@PLGA nanoparticles were designed with a polymer shell PLGA with the sonosensitizer IR780 loaded on. High-frequency diagnostic US was introduced to monitor the sonotherapeutic progression of bacterial myositis by therapeutic low-frequency US. Importantly, the in vitro and in vivo results confirmed that IR780@PLGA nanoparticles combined with US irradiation possess high efficiency for antibacterial therapy. This approach provides a simple and efficient strategy to monitor and combat MDR bacterial infection.

Keywords: IR780; antibacterial therapy; multidrug-resistant bacterial infections; reactive oxygen species; sonodynamic therapy.