ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

Jianxia Ou; Yanan Zhang; Yongmei Wang; Zherui Zhang; Hongping Wei; Junping Yu; Qi Wang; Guifeng Wang; Bo Zhang; Chunhe Wang

doi:10.1038/s41392-022-00913-3

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants

Signal Transduct Target Ther. 2022 Feb 9;7(1):43. doi: 10.1038/s41392-022-00913-3.

Authors

Jianxia Ou^#^{1

2}, Yanan Zhang^#^{3

4}, Yongmei Wang^#^{1

4}, Zherui Zhang^{3

4}, Hongping Wei^{3

4}, Junping Yu^{3

4}, Qi Wang¹, Guifeng Wang^{5

6}, Bo Zhang^{7

8}, Chunhe Wang^{9

10}

Affiliations

¹ Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China.
² School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
³ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
⁴ University of Chinese Academy of Sciences, Beijing, China.
⁵ Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China. gfwang@simm.ac.cn.
⁶ University of Chinese Academy of Sciences, Beijing, China. gfwang@simm.ac.cn.
⁷ Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zhangbo@wh.iov.cn.
⁸ University of Chinese Academy of Sciences, Beijing, China. zhangbo@wh.iov.cn.
⁹ Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China. wangc@simm.ac.cn.
¹⁰ University of Chinese Academy of Sciences, Beijing, China. wangc@simm.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme 2 / antagonists & inhibitors*
Angiotensin-Converting Enzyme 2 / genetics
Angiotensin-Converting Enzyme 2 / immunology
Animals
Antibodies, Neutralizing / pharmacology*
Antibodies, Viral / pharmacology*
COVID-19 / immunology
COVID-19 / virology
COVID-19 Drug Treatment*
Enzyme-Linked Immunosorbent Assay
Gene Expression
Host-Pathogen Interactions / genetics
Host-Pathogen Interactions / immunology
Humans
Lung / drug effects
Lung / immunology
Lung / virology
Mice
Protein Binding / drug effects
Receptors, Virus / antagonists & inhibitors*
Receptors, Virus / genetics
Receptors, Virus / immunology
SARS-CoV-2 / drug effects*
SARS-CoV-2 / growth & development
SARS-CoV-2 / immunology
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology

Substances

Antibodies, Neutralizing
Antibodies, Viral
Receptors, Virus
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
ACE2 protein, human
Angiotensin-Converting Enzyme 2

Supplementary concepts

SARS-CoV-2 variants