Synthetic approaches to 1,2,4-triazolo[5,1- c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir ("Triazavirin®") active against SARS-CoV-2 (COVID-19)

Grigory A Artem'ev; Vladimir L Rusinov; Dmitry S Kopchuk; Maria I Savchuk; Sougata Santra; Eugeny N Ulomsky; Grigory V Zyryanov; Adinath Majee; Weijie Du; Valery N Charushin; Оleg N Chupakhin

doi:10.1039/d1ob02125g

Synthetic approaches to 1,2,4-triazolo[5,1- c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir ("Triazavirin®") active against SARS-CoV-2 (COVID-19)

Org Biomol Chem. 2022 Mar 2;20(9):1828-1837. doi: 10.1039/d1ob02125g.

Authors

Grigory A Artem'ev^{1

2}, Vladimir L Rusinov^{1

2}, Dmitry S Kopchuk^{1

2}, Maria I Savchuk^{1

2}, Sougata Santra², Eugeny N Ulomsky^{1

2}, Grigory V Zyryanov^{1

2}, Adinath Majee³, Weijie Du⁴, Valery N Charushin^{1

2}, Оleg N Chupakhin^{1

2}

Affiliations

¹ I. Ya. Postovskiy Institute of Organic Synthesis, UB of the RAS, 22 S. Kovalevskoy Str., Yekaterinburg, 620219, Russian Federation.
² Ural Federal University, 19 Mira str., Yekaterinburg, 620002, Russian Federation. sougatasantra85@gmail.com.
³ Department of Chemistry; Visva-Bharati (A Central University), Santiniketan 731235, India.
⁴ Department of Pharmacology (State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150081, China.

PMID: 35137762
DOI: 10.1039/d1ob02125g

Abstract

Fragments of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one are found in many compounds with various types of biological activities, including the antiviral drug Riamilovir (Triazavirin®), which shows activity against SARS-CoV-2 (COVID-19). Therefore, the development of convenient methods for the synthesis of new derivatives of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one is always in demand. This review systematizes the information on the most common synthetic methods for constructing the 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one heterocyclic system.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Triazines*

Substances

Triazines