Mortality due to COVID-19 during the pandemic: A comparison of first, secondo and third SMAtteo COvid19 REgistry (SMACORE)

Valentina Zuccaro; Marta Colaneri; Erika Asperges; Pietro Valsecchi; Margherita Sambo; Laura Maiocchi; Paolo Sacchi; Alba Muzzi; Valeria Musella; Sara Cutti; Marco Rettani; Francesco Mojoli; Stefano Perlini; Angelo Guido Corsico; Antonio Di Sabatino; Enrico Brunetti; Raffaele Bruno; Catherine Klersy

doi:10.1016/j.heliyon.2022.e08895

Mortality due to COVID-19 during the pandemic: A comparison of first, secondo and third SMAtteo COvid19 REgistry (SMACORE)

Heliyon. 2022 Feb;8(2):e08895. doi: 10.1016/j.heliyon.2022.e08895. Epub 2022 Feb 3.

Authors

Valentina Zuccaro¹, Marta Colaneri¹, Erika Asperges¹, Pietro Valsecchi¹, Margherita Sambo¹, Laura Maiocchi¹, Paolo Sacchi¹, Alba Muzzi², Valeria Musella³, Sara Cutti², Marco Rettani², Francesco Mojoli^{4

5}, Stefano Perlini⁶, Angelo Guido Corsico⁷, Antonio Di Sabatino⁸, Enrico Brunetti^{1

5}, Raffaele Bruno^{1

5}, Catherine Klersy³

Affiliations

¹ U.O.C. Malattie Infettive I Fondazione IRCCS Policlinico San Matteo - Università di Pavia, Pavia, Italy.
² Direzione Medica di Presidio Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ Unità di Biometria e Epidemiologia Clinica- Direzione Scientifica Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁴ U.O.C. Anestesia e Rianimazione I Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁵ Dipartimento di Scienze Clinico-chirurgiche, Diagnostiche e Pediatriche - Università di Pavia, Italy.
⁶ U.O.C. Pronto Soccorso, Fondazione IRCCS Policlinico San Matteo, Dipartimento di Medicina Interna, Università di Pavia, Italy.
⁷ U.O.C. Pneumologia Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁸ U.O.C. Medicina Interna Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Abstract

COVID-19 tide had shattered on European countries with three distinct and tough waves, from March and April, 2020; October and November, 2020 and March and April, 2021 respectively. We observed a 50% reduction in the hazard of death during both wave II and III compared with wave I (HR 0.54, 95%CI 0.39-0.74 and HR 0.57, 95%CI 0.41-0.80, respectively). Sex and age were independent predictors of death. We compare in-hospital mortality of COVID-19 patients admitted at our Referral Hospital of Northern Italy during the different waves, discuss the reasons of the observed differences and suggest approaches to the challenges ahead.

Keywords: Covid-19; In-hospital mortality.