Research update of emergent gold nanoclusters: A reinforced approach towards evolution, synthesis mechanism and application

Imran Mahmood Khan; Sobia Niazi; Lin Yue; Yin Zhang; Imran Pasha; Muhammad Kashif Iqbal Khan; Wasim Akhtar; Ali Mohsin; Muhammad Farhan Jahangir Chughati; Zhouping Wang

doi:10.1016/j.talanta.2022.123228

Research update of emergent gold nanoclusters: A reinforced approach towards evolution, synthesis mechanism and application

Talanta. 2022 May 1:241:123228. doi: 10.1016/j.talanta.2022.123228. Epub 2022 Jan 17.

Authors

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; National Engineering Research Centre of Functional Food, Jiangnan University, Wuxi, China. Electronic address: imk2654@hotmail.com.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; National Engineering Research Centre of Functional Food, Jiangnan University, Wuxi, China. Electronic address: sobianiazi047@hotmail.com.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: yuelin@jiangnan.edu.cn.
⁴ Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu, 610106, China. Electronic address: zhangyin@cdu.edu.cn.
⁵ National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan. Electronic address: ipasha2001@uaf.edu.pk.
⁶ Department of Food Engineering, National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan. Electronic address: kashif.khan@uaf.edu.pk.
⁷ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: wasim_ju@hotmail.com.
⁸ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, PR China. Electronic address: alimohsin@ecust.edu.cn.
⁹ Department of Food Science and Technology, Khawaja Fared UEIT, Pakistan. Electronic address: farhan.chughtai@kfueit.edu.pk.
¹⁰ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; Key Laboratory of Meat Processing of Sichuan, Chengdu University, Chengdu, 610106, China; National Engineering Research Centre of Functional Food, Jiangnan University, Wuxi, China. Electronic address: wangzp1974@163.com.

PMID: 35131564
DOI: 10.1016/j.talanta.2022.123228

Abstract

Fluorescent biosensors and imaging devices have gained fervent consideration due to their prime functionality in biological. Among fluorescent nanomaterial (FNMs), the ultra-small gold nanoclusters (AuNCs) have gained promising attention with respect to extra-ordinary properties of bright fluorescence, economical synthesis, higher photostability, and biocompatibility, and deep tissue penetration. Therefore, the prior decades comprehended the revolutions in the field of real-time monitoring devices, nanotechnology-based biosensing, and bioimaging sensors. The present review primarily focuses on metal NCs (MNCs) and their advantages, a brief introduction of AuNCs along with history prospective and development, fundamental aspects regarding AuNCs quality and fluorescence, limitations and advantages of AuNCs, sensing mechanism, expected synthesis principle, and summarized the recent progress of AuNCs probe over the last 3 years (2019-2021) with their respective detection and bioimaging mechanism and synthesis principle. Moreover, the present work also serves as a novel stratagem for the preparation and potential applications of multifunctional AuNCs nano-systems responsiveness for various analytes detection and cell bioimaging with respective examples. At last, we described the challenges associated with the application of AuNCs based on recent signs of progress.

Keywords: AuNCs sensor; Detection. bioimaging; Fluorescence; History.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Fluorescent Dyes
Gold
Metal Nanoparticles*
Prospective Studies
Spectrometry, Fluorescence / methods

Substances

Fluorescent Dyes
Gold