A new juvenile hormone III, canangalia I (1), along with six known juvenile hormone III analogues (2-7), was isolated from the methanolic extract of Cananga latifolia stems. All structures were elucidated using spectroscopic data and compared with data from previous literature. Canangalia I (1) was found to be cytotoxic against human cervical adenocarcinoma (HeLa) cells with an IC50 value of 35.00 ± 2.15 µg/ml after 72 h, but was not toxic to Vero cells.
Keywords: Annonaceae; Cananga latifolia; cervical adenocarcinoma; cytotoxicity; juvenile hormone III.