Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers

Ghodsi Mohammadi Ziarani; Negar Jamasbi; Fatemeh Mohajer

doi:10.1007/s13659-022-00324-5

Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers

Nat Prod Bioprospect. 2022 Feb 7;12(1):3. doi: 10.1007/s13659-022-00324-5.

Authors

Ghodsi Mohammadi Ziarani¹, Negar Jamasbi², Fatemeh Mohajer²

Affiliations

¹ Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P. O. Box 1993893973, Tehran, Iran. gmohammadi@alzahra.ac.ir.
² Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, P. O. Box 1993893973, Tehran, Iran.

Abstract

Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies.

Keywords: Alexa leiopetala; Alexine; Natural products; Polyhydroxylated pyrrolizidine alkaloids.

Publication types

Review