Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions

Zhiyang Zhang; Zhengqi Bao; Penglian Gao; Junyi Yao; Peter Wang; Damin Chai

doi:10.3389/fcell.2021.802204

Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions

Front Cell Dev Biol. 2022 Jan 19:9:802204. doi: 10.3389/fcell.2021.802204. eCollection 2021.

Authors

Zhiyang Zhang¹, Zhengqi Bao², Penglian Gao¹, Junyi Yao¹, Peter Wang³, Damin Chai¹

Affiliations

¹ Department of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
² Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
³ Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical College, Bengbu, China.

Abstract

Accumulated evidence shows that the F-box protein 3 (FBXO3) has multiple biological functions, including regulation of immune pathologies, neuropathic diseases and antiviral response. In this review article, we focus on the role of FBXO3 in inflammatory disorders and human malignancies. We also describe the substrates of FBXO3, which contribute to inflammatory disorders and cancers. We highlight that the high expression of FBXO3 is frequently observed in rheumatoid arthritis, leukemia, pituitary adenoma, and oral squamous cell carcinoma. Moreover, we discuss the regulation of FBXO3 by both carcinogens and cancer preventive agents. Our review provides a comprehensive understanding of the role of FBXO3 in various biological systems and elucidates how FBXO3 regulates substrate ubiquitination and degradation during various physiological and pathological processes. Therefore, FBXO3 can be a novel target in the treatment of human diseases including carcinomas.

Keywords: Fbxo3; carcinomas; inflammation; rheumatoid arthritis; ubiquitination.

Publication types

Review