Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

Carolina Bonilla Gonzalez; Marcela Hincapié Echeverría; Rocio Plazas Pachón; Paola Mora Umaña; Berlly Lucia Diaz Gómez; Nathalie Gualdron Barreto

doi:10.3389/fped.2021.780258

Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

Front Pediatr. 2022 Jan 21:9:780258. doi: 10.3389/fped.2021.780258. eCollection 2021.

Authors

Carolina Bonilla Gonzalez¹, Marcela Hincapié Echeverría², Rocio Plazas Pachón², Paola Mora Umaña², Berlly Lucia Diaz Gómez³, Nathalie Gualdron Barreto¹

Affiliations

¹ Pediatric Intensive Care Unit, Department of Pediatrics, Fundación Santafe of Bogotá, Bogotá, Colombia.
² Pediatric Residents Andes University, Fundación Santafe of Bogotá, Bogotá, Colombia.
³ Department of Pathology, Fundación Santafe of Bogotá, Bogotá, Colombia.

Abstract

Background: We describe the first pediatric case of a 10-month-old boy with MIS-C who developed fulminant acute liver failure with associated giant cell transformation and a fatal outcome, after ruling out other infectious, metabolic, genetic, and autoimmune causes of liver failure following the usual algorithms for approaching the etiology. Although the patient received the main treatment strategies for liver failure, he had a fatal outcome. A clinical autopsy was considered as part of the diagnostic approach, which showed evidence of giant cell transformation.

Keywords: MIS-C; SARS-CoV-2; case report; cytokine storm; liver failure.

Publication types

Case Reports