Identification of lymph node metastasis by computed tomography in early gastric cancer

Jingtao Wei; Yinan Zhang; Zhilong Wang; Xiaojiang Wu; Ji Zhang; Zhaode Bu; Jiafu Ji

doi:10.21147/j.issn.1000-9604.2021.06.04

Identification of lymph node metastasis by computed tomography in early gastric cancer

Chin J Cancer Res. 2021 Dec 31;33(6):671-681. doi: 10.21147/j.issn.1000-9604.2021.06.04.

Authors

Jingtao Wei¹, Yinan Zhang¹, Zhilong Wang², Xiaojiang Wu¹, Ji Zhang¹, Zhaode Bu¹, Jiafu Ji¹

Affiliations

¹ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
² Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

PMID: 35125811
PMCID: PMC8742171
DOI: 10.21147/j.issn.1000-9604.2021.06.04

Abstract

Objective: Lymph node status is critical when selecting treatment methods for patients with early gastric cancer (EGC). The aim of this study was to assess the diagnostic value of computed tomography (CT) for detection of lymph node metastasis (LNM) in patients with EGC.

Methods: We retrospectively analyzed patients who had pathologically confirmed EGC between November 2010 and January 2019. After 1:1 propensity score matching, 65 patients with LNM and 65 patients without LNM were retained for comparison. The long diameter (LD) and short diameter (SD) of all visualized lymph nodes in all stations were recorded. The diagnostic value of LNM was assessed with receiver operating characteristic analysis.

Results: Among 130 patients, we found a total of 558 lymph nodes on the CT images. Among the diagnostic indicators, the number, sum of LD and sum of SD of lymph nodes greater than 3 mm had better discrimination. The areas under the curve were all greater than 0.75. As for different regions, the optimal cutoff values of number, the sum of LD and sum of SD were determined as follows: overall, ≥4, 19.9 mm and 13.5 mm; left gastric artery basin, ≥3, 15.7 mm and 8.6 mm; right gastroepiploic artery basin, ≥2, 8.6 mm and 7.0 mm.

Conclusions: CT is valuable for diagnosing LNM in EGC patients. The number, sum of LD and sum of SD of lymph nodes greater than 3 mm are preferable indicators. Different regional lymph nodes have different optimal criteria for predicting LNM in ECG patients.

Keywords: Computed tomography; early gastric cancer; lymphatic basin; lymphatic metastasis.