Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Jian Yang; Shasha Hu; Yangyang Bian; Jiangling Yao; Dong Wang; Xiaoqian Liu; Zhengdong Guo; Siyuan Zhang; Lei Peng

doi:10.3389/fcell.2021.789948

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Front Cell Dev Biol. 2022 Jan 18:9:789948. doi: 10.3389/fcell.2021.789948. eCollection 2021.

Authors

Jian Yang^{1

2

3}, Shasha Hu⁴, Yangyang Bian^{1

2

3}, Jiangling Yao^{1

2

3}, Dong Wang¹, Xiaoqian Liu¹, Zhengdong Guo^{1

2}, Siyuan Zhang¹, Lei Peng^{1

2

3}

Affiliations

¹ Trauma Center, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China.
² Key Laboratory of Emergency and Trauma Ministry of Education, Hainan Medical University, Haikou, China.
³ Hainan Provincial Biomaterials and Medical Device Engineering Technology Research Center, Hainan Medical University, Haikou, China.
⁴ Department of Pathology, Hainan General Hospital, Hainan Medical University, Haikou, China.

Abstract

New research has shown that the development of osteoarthritis (OA) is regulated by different mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of action among various cytokines, cell death processes and OA is important towards better understanding the pathogenesis and progression of the disease. This paper reviews the pathogenesis of OA in relation to different types of cytokine-triggered cell death. We describe the cell morphological features and molecular mechanisms of pyroptosis, apoptosis, necroptosis, and ferroptosis, and summarize the current research findings defining the molecular mechanisms of action between different cell death types and OA.

Keywords: apoptosis; ferroptosis; molecular mechanism; necroptosis; osteoarthritis; pyroptosis; signal pathway.

Publication types

Review