Zebrafish and idiopathic scoliosis: the 'unknown knowns'

Ziyang Liu; Yong Hai; Zhuoran Li; Lingyun Wu

doi:10.1016/j.tig.2022.01.002

Zebrafish and idiopathic scoliosis: the 'unknown knowns'

Trends Genet. 2022 Jun;38(6):524-528. doi: 10.1016/j.tig.2022.01.002. Epub 2022 Jan 31.

Authors

Ziyang Liu¹, Yong Hai², Zhuoran Li³, Lingyun Wu⁴

Affiliations

¹ Department of Orthopedics, Capital Medical University, Beijing, China; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: altanliu@gmail.com.
² Department of Orthopedics, Capital Medical University, Beijing, China; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: yong.hai@ccmu.edu.cn.
³ Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
⁴ Karolinska Institutet, Stockholm, Sweden.

PMID: 35115176
DOI: 10.1016/j.tig.2022.01.002

Abstract

The etiology and heterogeneity of idiopathic scoliosis (IS) are poorly understood. Studies using scoliotic zebrafish models have indicated a potential link between ciliary defects and scoliosis. They may further explain the onset of IS partially. However, it is necessary to further interpret the link between this progress and clinical medicine.

Keywords: ciliopathy; gene sequencing; heterogeneity; idiopathic scoliosis; motile cilia; zebrafish.

MeSH terms

Animals
Disease Models, Animal
Scoliosis* / genetics
Spine
Zebrafish Proteins
Zebrafish* / genetics

Substances

Zebrafish Proteins