A study on diffusion tensor imaging in patients with untreated first-episode obsessive-compulsive disorder

Bai-Ling Huang; Jun-Ru Wang; Xu-Huan Yang; Yu-Ming Ren; Hui-Rong Guo

doi:10.21037/qims-21-682

A study on diffusion tensor imaging in patients with untreated first-episode obsessive-compulsive disorder

Quant Imaging Med Surg. 2022 Feb;12(2):1467-1474. doi: 10.21037/qims-21-682.

Authors

Bai-Ling Huang¹, Jun-Ru Wang¹, Xu-Huan Yang¹, Yu-Ming Ren², Hui-Rong Guo¹

Affiliations

¹ Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Office of Academic Studies, Xinxiang Medical University, Xinxiang, China.

Abstract

Objective: The present study provides an overview of studies investigating white matter (WM) integrity in patients with obsessive-compulsive disorder (OCD) using diffusion tensor imaging (DTI). Furthermore, it studies the correlation of fractional anisotropy (FA) in abnormal cerebral WM areas with the course and clinical signs of the disease.

Methods: The study subjects were divided into two groups, the OCD group (n=38) and the control group (n=40), based on the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) diagnostic criteria for OCD. Patients with untreated first-episode OCD were assigned to the OCD group, while healthy volunteers were assigned to the control group. The study group was evaluated in accordance with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS). Subjects who met the inclusion criteria underwent whole-brain scanning via 3.0 T structural magnetic resonance imaging (sMRI). The WM FA values in different brain areas were compared between the two groups using voxel-based analysis (VBA). Subsequently, the correlations of the patient Y-BOCS score and disorder course with the FA values in significantly improved encephalic areas were analyzed.

Results: (I) The FA values of the right precentral gyrus (PreCG.R), left insular lobe, left inferior frontal gyrus and right inferior occipital gyrus (Occipital_Inf_R) WM were significantly lower in the OCD group than in the control group (P<0.05). Elevated FA values were not observed in the OCD group. (II) FA values of PreCG.R, left insular lobe/left inferior frontal gyrus, and Occipital_Inf_R were not found in relation to the total Y-BOCS score (P=0.122; P=0.401; P=0.134), obsessional thoughts score (P=0.299; P=0.760; P=0.062), compulsive activities checklist (P=0.487; P=0.420; P=0.431), and disease course (P=0.604; P=0.380; P=0.182).

Conclusions: Multiple microstructural cerebral WM changes were observed in the frontal lobe, occipital lobe, and insula in patients with untreated first-episode OCD, presenting the correlation of these changes with OCD occurrence.

Keywords: Obsessive-compulsive disorder (OCD); diffusion tensor imaging (DTI); magnetic resonance imaging (MRI); white matter (WM).