The Role and Application of Exosomes in Gastric and Colorectal Cancer

Qirong Li; Dongxu Wang; Dayong Ding; Ye Feng; Ruizhi Hou; Dianfeng Liu; Chao Lin; Yongjian Gao

doi:10.3389/fphar.2021.825475

The Role and Application of Exosomes in Gastric and Colorectal Cancer

Front Pharmacol. 2022 Jan 17:12:825475. doi: 10.3389/fphar.2021.825475. eCollection 2021.

Authors

Qirong Li^{1

2}, Dongxu Wang², Dayong Ding¹, Ye Feng¹, Ruizhi Hou¹, Dianfeng Liu², Chao Lin³, Yongjian Gao¹

Affiliations

¹ Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
² Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
³ School of Grain Science and Technology, Jilin Business and Technology College, Changchun, China.

Abstract

Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes-small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.

Keywords: cancer therapy; colorectal cancer; exosomes; gastric cancer; ncRNA.

Publication types

Review