GM-CSF: Orchestrating the Pulmonary Response to Infection

Thomas S McCormick; Rana B Hejal; Luis O Leal; Mahmoud A Ghannoum

doi:10.3389/fphar.2021.735443

GM-CSF: Orchestrating the Pulmonary Response to Infection

Front Pharmacol. 2022 Jan 17:12:735443. doi: 10.3389/fphar.2021.735443. eCollection 2021.

Authors

Thomas S McCormick¹, Rana B Hejal^{2

3}, Luis O Leal⁴, Mahmoud A Ghannoum^{1

5}

Affiliations

¹ Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, OH, United States.
² Medical Intensive Care Unit, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.
³ Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland, OH, United States.
⁴ Partner Therapeutics, Lexington, MA, United States.
⁵ University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Abstract

This review summarizes the structure and function of the alveolar unit, comprised of alveolar macrophage and epithelial cell types that work in tandem to respond to infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) helps to maintain the alveolar epithelium and pulmonary immune system under physiological conditions and plays a critical role in restoring homeostasis under pathologic conditions, including infection. Given the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and global spread of coronavirus disease 2019 (COVID-19), with subsequent acute respiratory distress syndrome, understanding basic lung physiology in infectious diseases is especially warranted. This review summarizes clinical and preclinical data for GM-CSF in respiratory infections, and the rationale for sargramostim (yeast-derived recombinant human [rhu] GM-CSF) as adjunctive treatment for COVID-19 and other pulmonary infectious diseases.

Keywords: COVID-19; GM-CSF; acute respiratory distress syndrome; alveolar macrophage; granulocyte-macrophage colony-stimulating factor; immune response; respiratory infections; sargramostim.

Publication types

Review