The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucleus or the cell membrane. ERp57/PDIA3 is an important research target considering it can be found in various subcellular locations. This protein is involved in many different physiological and pathological processes, and our review describes new data on its functions and summarizes some ligands identified as PDIA3-specific inhibitors.
Keywords: Cancer; Cardiovascular system; ERp57; Fertility; Infections; Nervous system; PDI inhibitors; PDIA3; Punicalagin; Vitamin D3.
© 2022. The Author(s).