Biomedical applications of chitosan-graphene oxide nanocomposites

Wenjun Feng; Zhengke Wang

doi:10.1016/j.isci.2021.103629

Biomedical applications of chitosan-graphene oxide nanocomposites

iScience. 2021 Dec 13;25(1):103629. doi: 10.1016/j.isci.2021.103629. eCollection 2022 Jan 21.

Authors

Wenjun Feng¹, Zhengke Wang¹

Affiliation

¹ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Abstract

Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers. Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS-GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.

Keywords: Biomaterials; Composite materials; Materials science.

Publication types

Review