Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment

Nanotechnology. 2022 Feb 21;33(20). doi: 10.1088/1361-6528/ac504c.

Abstract

Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged.

Keywords: Ehrlich tumor; elderly mice; maghemite nanoparticles; magnetic hyperthermia; mathematical modeling; selol-loaded PLGA-nanocapsule.

MeSH terms

  • Animals
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Carcinoma, Ehrlich Tumor / pathology
  • Carcinoma, Ehrlich Tumor / therapy
  • Cell Cycle / drug effects
  • Combined Modality Therapy
  • DNA Fragmentation / drug effects
  • Female
  • Hyperthermia, Induced*
  • Magnetite Nanoparticles / chemistry
  • Magnetite Nanoparticles / therapeutic use*
  • Magnetite Nanoparticles / ultrastructure
  • Mice
  • Nanocapsules / chemistry
  • Nanocapsules / therapeutic use*
  • Nanocapsules / ultrastructure
  • Selenium Compounds / chemistry
  • Selenium Compounds / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Tumor Burden / drug effects

Substances

  • Magnetite Nanoparticles
  • Nanocapsules
  • Selenium Compounds
  • selol