Usability, acceptability, and feasibility of a High-Density Microarray Patch (HD-MAP) applicator as a delivery method for vaccination in clinical settings

Hum Vaccin Immunother. 2022 Nov 30;18(4):2018863. doi: 10.1080/21645515.2021.2018863. Epub 2022 Jan 31.

Abstract

Background: High-density microarray patch (HD-MAP) vaccines may increase vaccine acceptance and use. We aimed to ascertain whether professional immunizers (PIs) and other healthcare workers (HCWs) in Australia, a High-Income Country (HIC), found the HD-MAP applicator usable and acceptable for vaccine delivery.

Methods: This feasibility study recruited PIs and HCWs to administer/receive simulated HD-MAP administration, including via self-administration. We assessed usability against essential and desirable criteria. Participants completed a survey, rating their agreement to statements about HD-MAP administration. A subset also participated in an interview or focus group. Survey data were analyzed using descriptive statistics, and interviews were transcribed and subject to thematic analysis.

Results: We recruited 61 participants: 23 PIs and 38 HCWs. Findings indicated high usability and acceptability of HD-MAP use across both groups by a healthcare professional or trained user and for self-administration with safety measures in place. Most administrations met essential criteria, but PIs, on average, applied the HD-MAP for slightly less time than the required 10-seconds, which the HCWs achieved. PIs perceived safety concerns about home administration but found layperson self-administration acceptable in an emergency, pandemic, and rural or remote settings.

Conclusions: Participants found HD-MAP administration usable and acceptable. Usability and acceptability are likely to be improved through end-user education and training.

Keywords: High-Density Microarray Patch (HD-MAP); Microarray patch; acceptability; self-administration; usability; vaccination patch.

Plain language summary

Professional immunizers and healthcare workers found high-density microarray patch devices highly usable and acceptable to administer vaccines.HD-MAPs may have advantages over intramuscular injections in clinical settings and in pandemics.Vaccination with HD-MAP may improve acceptance for those with needle-related anxiety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Australia
  • Feasibility Studies
  • Health Personnel
  • Humans
  • Vaccination*
  • Vaccines*

Substances

  • Vaccines

Grants and funding

This study was supported by the Australian Government’s Department of Industry, Innovation and Science (Innovative Manufacturing Cooperative Research Centre [IMCRC] Ltd.) in partnership with Vaxxas Pty Ltd (IMCRC/VAX/14112018). This study has not been previously presented.