Biologic therapy for Crohn's disease over the last 3 decades

Ji-Liang Shen; Zheng Zhou; Jia-Sheng Cao; Bin Zhang; Jia-Hao Hu; Jia-Ying Li; Xiao-Ming Liu; Sarun Juengpanich; Ming-Song Li; Xu Feng

doi:10.12998/wjcc.v10.i2.594

Biologic therapy for Crohn's disease over the last 3 decades

World J Clin Cases. 2022 Jan 14;10(2):594-606. doi: 10.12998/wjcc.v10.i2.594.

Authors

Affiliations

¹ Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China.
² Department of Gastroenterology, Nan Fang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
³ Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China. phoneshe@zju.edu.cn.

Abstract

Background: Despite the overload of publications on Crohn's disease (CD), no comprehensive analysis of biologic therapy for CD has been reported.

Aim: To determine knowledge gaps and identify areas of interest of biologic therapy for CD.

Methods: The top 100 highest-cited original articles were identified from January 1991 to December 2020 in the Clarivate Analytics Web of Science Core Collection database. We conducted a bibliometric analysis of biologic therapy for CD based on total citations, summarized the bibliographic information of the articles related to CD biologic therapy, and explored the research hotspots.

Results: The top 100 highest-cited original articles were identified with total citations ranging from 307 to 2978. The 2000s (Period II, n = 66) yielded the most influential original articles and saw the most dramatic growth. Among the top 10 countries, including 8 European countries and 2 North American countries, the United States (n = 37) and Belgium (n = 20) contributed the most publications. Among the top 10 institutions, the University Hospital Gasthuisberg in Belgium (n = 23), the University of Chicago in the United States (n = 20), and the Mayo Clinic in the United States (n = 17) published the most papers. Regarding authors, Rutgeerts P in Belgium (n = 32), Sandborn WJ in the United States (n = 23), and Feagan BG in Canada (n = 18) published the highest number of studies. The cooperation relationships between the United States and Europe were most frequent. Gastroenterology (impact factor = 22.682) published the most articles on biologic therapy for CD (n = 32) with 17654 total citations. Anti-tumor necrosis factor biologics and monoclonal antibodies were the most studied topics.

Conclusion: The bibliometric analysis emphasized the key contributions to the development of the specialized field. These data would provide useful research insights into biologic therapy for CD for clinicians and researchers.

Keywords: Bibliometric analysis; Biologic therapy; Crohn’s disease; Insight; Most influential.