Molecular Mechanisms of Exercise on Cancer: A Bibliometrics Study and Visualization Analysis via CiteSpace

Dongling Zhong; Yuxi Li; Yijie Huang; Xiaojuan Hong; Juan Li; Rongjiang Jin

doi:10.3389/fmolb.2021.797902

Molecular Mechanisms of Exercise on Cancer: A Bibliometrics Study and Visualization Analysis via CiteSpace

Front Mol Biosci. 2022 Jan 13:8:797902. doi: 10.3389/fmolb.2021.797902. eCollection 2021.

Authors

Dongling Zhong¹, Yuxi Li², Yijie Huang³, Xiaojuan Hong², Juan Li¹, Rongjiang Jin¹

Affiliations

¹ School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
² School of Acupuncture Moxibustion and Tuina, The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
³ The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Abstract

Objective: To analyze the research hot spots and frontiers of molecular mechanisms of exercise on cancer via CiteSpace. Method: Related publications in the Web of Science Core Collection Science Citation Index Expanded were retrieved from inception to November 27th, 2021. Then we used CiteSpace to generate network maps and identify top authors, institutions, countries, keywords, co-cited authors, journals, references and research trends. Results: A total of 1,130 related publications were retrieved. The most productive author and journal were Lee W Jones and PLOS ONE. Hanahan D and Warburg O were the most cited authors. Fudan University and Shanghai Jiao Tong University were the leading institutions, while China was the leading country. Top-cited authors and references generally focused on the epidemiology and hallmarks of cancer. Top five keywords with both high frequency and high betweenness centrality were breast cancer, aerobic glycolysis, oxidative stress, gene expression, skeletal muscle. Keyword "warburg effect" ranked first with the highest citation burst, while "inflammation", "hepatocellular carcinoma", "epithelial mesenchymal transition", and "adipose tissue" were emerging research foci. Conclusion: This study analyzed the research hot spots and frontiers of molecular mechanisms of exercise on cancer via CiteSpace. Based on the results, altered metabolism (aerobic glycolysis, insulin resistance, myokines), oxidative stress, gene expression and apoptosis were hot-research mechanisms of exercise on cancer. Emerging research foci of mechanisms were generally around inflammation, epithelial mesenchymal transition and adipokines. In addition, future studies could carry in-depth research of interactions between different mechanisms and try to elucidate the recommended doses and intensities of exercise for cancer, especially in breast, colorectal, prostate cancer and hepatocellular carcinoma.

Keywords: bibliometrics; cancer; citespace; exercise; molecular mechanisms; visualization analysis.

Publication types

Review