BMI, Blood Pressure, and Plasma Lipids among Centenarians and Their Offspring

Peng-Cheng Hai; Dong-Xiao Yao; Rui Zhao; Chen Dong; Sara Saymuah; Yue-Song Pan; Zhi-Feng Gu; Yi-Long Wang; Chen Wang; Jian-Lin Gao

doi:10.1155/2022/3836247

BMI, Blood Pressure, and Plasma Lipids among Centenarians and Their Offspring

Evid Based Complement Alternat Med. 2022 Jan 20:2022:3836247. doi: 10.1155/2022/3836247. eCollection 2022.

Authors

Peng-Cheng Hai¹, Dong-Xiao Yao², Rui Zhao³, Chen Dong³, Sara Saymuah⁴, Yue-Song Pan², Zhi-Feng Gu³, Yi-Long Wang², Chen Wang^{1

5}, Jian-Lin Gao³

Affiliations

¹ School of General Practice and Continuing Education, Capital Medical University, Fengtai, No. 10, You An Men Wai Xi Tou Tiao, Beijing 100069, China.
² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
³ Research Center of Gerontology and Longevity, Affiliated Hospital of Nantong University, Nantong, China.
⁴ Department of Neurosurgery, Wayne State University School of Medicine, Detroit, USA.
⁵ Department of General Practice, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Abstract

Background: The burden of cardiovascular diseases (CVDs) is increasing substantially due to population growth and aging. Determining effective prevention and understanding the underlying mechanisms remain desirable pursuits for increasing the quality of life. As centenarians and their offspring may have genetic advantages, they may present with healthier cardiovascular-related profiles.

Methods: We launched a cross-sectional household-based survey of centenarian families, including 253 centenarians, 217 centenarian offspring, and 116 offspring spouses without centenarian parents from county-level Chinese longevity city Rugao. Among offspring and offspring spouses were the following arrangements: 101 paired offspring and offspring spouses who lived together, 116 unpaired offspring, and 16 unpaired spouses. We investigated their cardiovascular-related health status including waist circumference, body mass index (BMI), blood pressure, and plasma lipids and compared results among centenarians, centenarian offspring, and offspring spouses.

Results: Centenarians ranged from 99 to 109 years with a median age of 100 years. Centenarian offspring, with a median age of 70 years, and offspring spouses, with a median age of 69 years, shared similar age. Results of blood pressure, plasma lipid levels, and BMI displayed no significant difference between centenarian offspring and offspring spouses. However, centenarians appeared to have lower waist circumference, BMI, TC, LDL-C, TG, and diastolic blood pressure but higher levels of systolic blood pressure (p < 0.05). Multivariate analysis showed the prevalence of obesity, hypertension, and dyslipidemia was similar between centenarian offspring and offspring spouses, while centenarians appeared to have a lower prevalence of obesity and a higher prevalence of hypertension (p < 0.05).

Conclusions: Centenarians and centenarian offspring did not present healthier BMI, blood pressure, or plasma lipids than offspring spouses. Further research on longevity and cardiovascular diseases are desirable.