Risk and Protective Factors for Postoperative Complications in Elderly Patients With Colorectal Cancer

Anticancer Res. 2022 Feb;42(2):1123-1130. doi: 10.21873/anticanres.15575.

Abstract

Aim: This study aimed to evaluate perioperative factors, including nutritional status and sarcopenia on short-term postoperative complications, determine the risk factors for postoperative complications, and clarify potential preoperative interventions and optimal surgical procedures to improve short-term outcomes in elderly patients with colorectal cancer (CRC).

Patients and methods: This retrospective, single-centre cohort study analysed the factors and short-term postoperative complications of CRC in a cohort of 101 patients aged ≥80 years who underwent radical resection between 2013 and 2020. Nutritional status was evaluated by calculating the controlling nutritional status.

Results: The median age was 83 years, and the frequency of sarcopenia was 39.6%. Short-term postoperative complications occurred in 24 patients. Risk factors for short-term postoperative complications in multivariate analysis were sarcopenia combined with nutritional disorders and open surgical approach.

Conclusion: The status of nutrition and sarcopenia must be considered in order to predict and improve postoperative outcomes. If possible, a laparoscopic approach should be selected to prevent poor postoperative outcomes.

Keywords: Colorectal cancer patients; elderly; postoperative complications; protective factors; risk factors.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Cohort Studies
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / surgery*
  • Comorbidity
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Nutritional Status / physiology
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Protective Factors
  • Retrospective Studies
  • Risk Factors
  • Sarcopenia / complications
  • Sarcopenia / epidemiology