Eurobusones A-D, four antibacterial formyl phloroglucinol meoterpenoids from Eucalyptus robusta

Fitoterapia. 2022 Mar:157:105131. doi: 10.1016/j.fitote.2022.105131. Epub 2022 Jan 31.

Abstract

Four antibacterial formyl phloroglucinol meroterpenoids (FPMs), eurobusones A-D (1-4), as well as six known analogues (5-10), were isolated from the leaves of Eucalyptus robusta. Their structures were determined by the analysis of spectroscopic data and electron circular dichroism (ECD) calculation, along with the application of Snatzke helicity rules. Among them, compounds 2 and 8-10 showed good activity against Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis with MIC50 values less than 1.00 μg/mL.

Keywords: Antibacterial activity; Eucalyptus robusta; Formyl phloroglucinol meroterpenoids.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Circular Dichroism
  • Escherichia coli / drug effects
  • Eucalyptus / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Terpenes / chemistry*
  • Terpenes / pharmacology

Substances

  • Anti-Bacterial Agents
  • Terpenes