Sex differences in ventricular arrhythmia: epidemiology, pathophysiology and catheter ablation

Philipp Krisai; Ghassen Cheniti; Takamitsu Takagi; Tsukasa Kamakura; Elodie Surget; Clémentine André; Josselin Duchateau; Thomas Pambrun; Nicolas Derval; Frédéric Sacher; Pierre Jaïs; Michel Haïssaguerre; Mélèze Hocini

doi:10.31083/j.rcm2301014

Sex differences in ventricular arrhythmia: epidemiology, pathophysiology and catheter ablation

Rev Cardiovasc Med. 2022 Jan 14;23(1):14. doi: 10.31083/j.rcm2301014.

Affiliation

¹ Electrophysiology and Ablation Unit and LIRYC, 33600 CHU de Bordeaux, France.

PMID: 35092206
DOI: 10.31083/j.rcm2301014

Abstract

Evidence on sex differences in the pathophysiology and interventional treatment of ventricular arrhythmia in ischemic (ICM) or non-ischemic cardiomyopathies (NICM) is limited. However, women have different etiologies and types of structural heart disease due to sex differences in genetics, proteomics and sex hormones. These differences may influence ventricular electrophysiological parameters and may require different treatment strategies. Considering that women were consistently under-represented in all randomized-controlled trials on VT ablation, the applicability of the study results to female patients is not known. In this article, we review the current knowledge and gaps in evidence about sex differences in the epidemiology, pathophysiology and catheter ablation in patients with ventricular arrhythmias.

Keywords: Catheter ablation; Sex difference; Ventricular arrhythmia; Ventricular tachycardia.

Publication types

Review

MeSH terms

Arrhythmias, Cardiac / diagnosis
Arrhythmias, Cardiac / epidemiology
Arrhythmias, Cardiac / therapy
Cardiomyopathies*
Catheter Ablation* / adverse effects
Female
Humans
Male
Randomized Controlled Trials as Topic
Sex Characteristics
Tachycardia, Ventricular* / etiology
Treatment Outcome