A class of novel myricetin derivatives containing 1,3,4-oxadiazole bisthioether were synthesized. The results of antiviral biological activity demonstrated that the partially compounds exhibited good antiviral effects against tobacco mosaic virus. The in vivo curative and protective activities of compound E12 against TMV was quite significant. The EC50 value of the curative activity of E12 was 128.8 μg/mL, while the value of ningnanmycin was 296.4 μg/mL. Similarly, the EC50 value of the protective activity of E12 was 99.1 μg/mL, while the value of ningnanmycin was 307.6 μg/mL. The microscale thermophoresis data indicated that the binding value of ningnanmycin and TMV-CP was 2.726±1.301 μM, which was not as good as the binding value of E12 and TMV-CP was 0.029±0.013 μM. This study showed that novel myricetin derivatives containing 1,3,4-oxadiazole bisthioether may be a kind of agricultural antiviral drugs with great potential.
Keywords: 1,3,4-oxadiazole bisthioether; TMV-CP; antiviral activity; myricetin derivatives.
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