Systematic comparison of basic animal models of cerebral hypoperfusion

V Chrishtop; V Nikonorova; A Gutsalova; T Rumyantseva; M Dukhinova; А Salmina

doi:10.1016/j.tice.2021.101715

Systematic comparison of basic animal models of cerebral hypoperfusion

Tissue Cell. 2022 Apr:75:101715. doi: 10.1016/j.tice.2021.101715. Epub 2021 Dec 23.

Authors

V Chrishtop¹, V Nikonorova², A Gutsalova², T Rumyantseva³, M Dukhinova², А Salmina⁴

Affiliations

¹ SCAMT Institute, ITMO University, St. Petersburg, Russia. Electronic address: chrishtop@scamt-itmo.ru.
² SCAMT Institute, ITMO University, St. Petersburg, Russia.
³ Yaroslavl State Medical University, Yaroslavl, Russia.
⁴ Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Research Center of Neurology, Moscow, Russia.

PMID: 35086651
DOI: 10.1016/j.tice.2021.101715

Abstract

Various surgical interventions into the head and neck vasculature differentially impact nature, localization and dynamics of ischemic changes in the brain structures. In this regard, our review aims to compare the time course of basic cellular and molecular mechanisms. Selection of a animals model should be done along the following criteria: development of oxidative stress in brain cells, blood-brain barrier breakdown, glial activation and neuroinflammation, alterations in angiogenesis; reproducibility of the model.

Keywords: Animal models of cerebral hypoperfusion; Glia; Neurons; Periodization.

Publication types

Review

MeSH terms

Animals
Brain*
Disease Models, Animal
Oxidative Stress*
Reproducibility of Results