A ZIF-8-based multifunctional intelligent drug release system for chronic osteomyelitis

Yongmei Ge; Kui Wang; Jiayi Liu; Ye Tian; Huili Li; HuiZhen Wang; Zhaowei Lin; Mingxia Qiu; Bin Tang

doi:10.1016/j.colsurfb.2022.112354

A ZIF-8-based multifunctional intelligent drug release system for chronic osteomyelitis

Colloids Surf B Biointerfaces. 2022 Apr:212:112354. doi: 10.1016/j.colsurfb.2022.112354. Epub 2022 Jan 21.

Authors

Yongmei Ge¹, Kui Wang², Jiayi Liu³, Ye Tian⁴, Huili Li⁵, HuiZhen Wang³, Zhaowei Lin⁶, Mingxia Qiu⁷, Bin Tang⁸

Affiliations

¹ Harbin Institute of Technology, Harbin, Heilongjiang 150001, China; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
² Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China; Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
³ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
⁴ Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
⁵ Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
⁶ Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China.
⁷ College of New Materials and New Energies, Shenzhen Technology University, Shenzhen, Guangdong 518055, China. Electronic address: qiumingxia@sztu.edu.cn.
⁸ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address: tangb@sustech.edu.cn.

PMID: 35085938
DOI: 10.1016/j.colsurfb.2022.112354

Abstract

Chronic osteomyelitis (COM) is an inflammatory bone disease caused by bacterial infection. Conventional treatment with antibiotics is prone to resistance and other side effects, and it is ineffective against inflammation caused by infection and bone loss. To treat COM comprehensively, based on the acidic microenvironment of osteomyelitis, we used ZIF-8 and celecoxib to construct a multifunctional intelligent drug release system with pH response effect, named CEL@ZIF-8. Material characterization revealed that celecoxib is successfully loaded into ZIF-8. Ion release and drug release experiments indicated that CEL@ZIF-8 can respond well to the pH and intelligently control the release of ions and drugs. Antibacterial assays manifested that CEL@ZIF-8 is able to inhibit the growth of bacteria significantly. In vitro cell experiments demonstrated that CEL@ZIF-8 can significantly up-regulate the expression of osteogenesis-related cytokines and down-regulate the levels of inflammatory factors. Studies verify that the novel drug release system possesses multiple functions: antibacterial, osteogenesis, anti-inflammatory and intelligent release, suggesting a tremendous clinical promise for the treatment of COM.

Keywords: Anti-inflammatory; Antibacterial; Chronic osteomyelitis; Intelligent release; Osteogenesis.

MeSH terms

Anti-Bacterial Agents / pharmacology
Bacteria
Drug Liberation
Humans
Osteogenesis
Osteomyelitis* / drug therapy

Substances

Anti-Bacterial Agents