COVID-19 Associated Bacteremia with Chryseobacterium indologenes Co-Harboring bla IND-2, bla CIA and bla CcrA

Ting-Kuang Yeh; Zong-Hao Li; Yao-Ting Huang; Po-Yu Liu

doi:10.2147/IDR.S347066

COVID-19 Associated Bacteremia with Chryseobacterium indologenes Co-Harboring bla _IND-2, bla _CIA and bla _CcrA

Infect Drug Resist. 2022 Jan 20:15:167-170. doi: 10.2147/IDR.S347066. eCollection 2022.

Authors

Ting-Kuang Yeh¹, Zong-Hao Li², Yao-Ting Huang², Po-Yu Liu^{1

3

4}

Affiliations

¹ Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Department of Computer Science and Information Engineering, National Chung Cheng University, Chiayi, Taiwan.
³ Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
⁴ Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.

Abstract

We report a COVID-19 case with carbapenem resistant Chryseobacterium indologenes bacteremia. Whole genome sequencing identified the presence of bla _IND-2, bla _CIA and bla _CcrA. To our knowledge, this is the first report of Chryseobacterium indologenes complicating COVID-19 and the detection of bla _CcrA in C. indologenes. The presence of bla _CcrA in Chryseobacterium was overlooked previously may related to substantial sequence divergence with the original allele in Bacteroides fragilis. Antimicrobial resistance (AMR) is a challenge to global health in the age of COVID-19 pandemic. Further study and surveillance of underlying mechanisms is needed.

Keywords: COVID-19; Chryseobacterium indologenes; SARS-CoV-2; resistance.

Publication types

Case Reports

Grants and funding

YTH was supported in part by the Ministry of Science and Technology (109-2221-E-194-038-MY3). PYL was supported in part by the Ministry of Science and Technology (110-2314-B-075A-011) and Taichung Veterans General Hospital (TCVGH-1103901C and TCVGH-1103901D).