Abstract
Herein, we report an inorganic photothermal agent, CuS- and an organic photosensitizer, BODIPY-loaded composite nanoscale COF material via a stepwise post-synthetic modification. The obtained CuS@COF-BDP can be a dual-modal therapeutic agent to highly inhibit MCF-7 tumor cell proliferation due to its efficient singlet oxygen generation and photothermal conversion abilities.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Boron Compounds / chemistry
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Boron Compounds / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Copper / chemistry
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Copper / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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MCF-7 Cells
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Metal-Organic Frameworks / chemical synthesis
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Molecular Structure
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Particle Size
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Photothermal Therapy*
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Singlet Oxygen / metabolism
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Structure-Activity Relationship
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Antineoplastic Agents
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Boron Compounds
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Metal-Organic Frameworks
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Photosensitizing Agents
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Singlet Oxygen
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Copper
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cupric sulfide