A CuS- and BODIPY-loaded nanoscale covalent organic framework for synergetic photodynamic and photothermal therapy

Chem Commun (Camb). 2022 Feb 15;58(14):2387-2390. doi: 10.1039/d1cc06330h.

Abstract

Herein, we report an inorganic photothermal agent, CuS- and an organic photosensitizer, BODIPY-loaded composite nanoscale COF material via a stepwise post-synthetic modification. The obtained CuS@COF-BDP can be a dual-modal therapeutic agent to highly inhibit MCF-7 tumor cell proliferation due to its efficient singlet oxygen generation and photothermal conversion abilities.

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Boron Compounds / chemistry
  • Boron Compounds / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Copper / chemistry
  • Copper / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • MCF-7 Cells
  • Metal-Organic Frameworks / chemical synthesis
  • Metal-Organic Frameworks / chemistry
  • Metal-Organic Frameworks / pharmacology*
  • Molecular Structure
  • Particle Size
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Photothermal Therapy*
  • Singlet Oxygen / metabolism
  • Structure-Activity Relationship

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Antineoplastic Agents
  • Boron Compounds
  • Metal-Organic Frameworks
  • Photosensitizing Agents
  • Singlet Oxygen
  • Copper
  • cupric sulfide