Highlights of Cardiovascular Disease Studies Presented at the 2021 American Heart Association Scientific Sessions

Curr Atheroscler Rep. 2022 Jan;24(1):61-72. doi: 10.1007/s11883-022-00985-0. Epub 2022 Jan 24.

Abstract

Purpose of review: This review highlights major studies across a broad array of topics presented at the virtual 2021 American Heart Association (AHA) Scientific Sessions.

Recent findings: Assessed studies examine a remotely delivered hypertension and lipid program in 10,000 patients across a diverse healthcare network; a cluster-randomized trial of a village doctor-led intervention for hypertension control; empagliflozin in heart failure with preserved ejection fraction (EMPEROR-Preserved); efficacy and safety of empagliflozin in hospitalized heart failure patients (EMPULSE); icosapent ethyl versus placebo in outpatients with coronavirus disease 2019 (PREPARE-IT 2); clinical safety, pharmacokinetics, and low-density lipoprotein cholesterol-lowering efficacy of MK-0161, an oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor; and effects of aspirin on dementia and cognitive impairment in the ASCEND trial. Research presented at the 2021 AHA Scientific Sessions emphasized the importance of interventions for cardiovascular disease prevention.

Keywords: Aspirin; Atherosclerotic cardiovascular disease; Cardiovascular prevention; Empagliflozin; Heart failure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • American Heart Association
  • Anticholesteremic Agents* / therapeutic use
  • COVID-19
  • Cardiovascular Diseases* / drug therapy
  • Cardiovascular Diseases* / prevention & control
  • Humans
  • Proprotein Convertase 9
  • Randomized Controlled Trials as Topic
  • United States / epidemiology

Substances

  • Anticholesteremic Agents
  • PCSK9 protein, human
  • Proprotein Convertase 9